I would say that Strahan is the best. However, I would not consider Lou's speech impediment a lisp, I think it is more of a case of his tongue being in the way, inhibiting proper sounding speech.
i like strahan and sharpe, but dr. lou literally makes me gag. t&p for mrs. holtz who's had to endure sloppy kisses from that tongue for lord knows how long.
i'm gonna have to give shannon the nod on this one, he's imho hands down the funniest guy in football.