Looking to buy a used F150 or Tundra 2017 or newer. Which has best best and most comfortable ride. Will 2wd or 4wd be better. Thanks

A bit of a tricky answer here but dropping my opinion.
2017-2020 F150 vs 2017-2021 Tundra: comfort and best overall package goes to the Tundra.
21+ F150 vs 22+ Tundra: comfort and best overall package goes to Ford, though both are solid options. I found the tech to be a bit better in the F150 and more user friendly.

Fords have better tech and more perks/options for the price. Toyotas tend to be more reliable. The new fords ride extremely nice compared to the older models. However, I believe Tundras are now independent rear suspension so they should in theory ride better. Never been in a new one though.

I've owned and sold both and that's a hard one bc it's so subjective. I'd suggest you sit in both and see which one you like the best.

Ford ride is smoother, tundra will last longer with much less upkeep.

I have a 2021 Tundra and love it. The Tundra feels dated on the interior compared to others, but that is kind of by design. Toyota tends to stick with what works and is proven while its competitors tend to put the the latest technology in its cars first. If you go with a Tundra, I'd get a 2018 or newer. That's the year they updated the grill and it got features like adaptive cruise standard I think. Not sure what year apple car play became standard thoughthat might've been 2018 also

I'm in my 40s now and have had Ford, Chevy, Nissan, and Toyota vehicles since I got my drivers license at 16. My wife has driven nothing but Toyotas since she was teenager including the RAV4 we bought 7 years ago .

With that said, I'm a big fan of Toyota. Hands down, it's been the best in terms of quality. Probably all I'll ever own again as far as a practical daily driver.