Highway 6 South is the fastest way to go, PERIOD.
The only people that say otherwise (about 59-toll-45) are ADD and cant stand at sitting at lights.
I travel back and fourth weekly and its the fastest if you live off HWY 6. I live in First Colony, so Im right there.
From the place in midtown, though- it takes 45 minutes to get there on 45! So nice...