Looking for recommendations on a 45 suppressor.

Initial host will be a MP5 clone with a 3 lug. I already have access to a 9mm Octane HD of which I am thoroughly impressed with on that host.

I want to add a 45 (no host currently) since I have access to a 9 and want to expand my trust's collection.

I was looking at the Tirant 45M but the weight seems high. Thoughts?

You answered your own question. Octane 45.

I have an AAC tirant and an octane 45k. Both are great. The octane works for 300blk too which is an attractive option

I have an Octane 45. Great can. Waiting on a Dead Air Ghost which can be configured as a full size or "K" config which is a shorter version of itself, albeit with less suppression in that config.

I have an octane 45HD. Highly recommend.

Liberty Cosmic. Light weight but can still handle many of the rifles.

https://libertycans.net/cosmic/

I ordered a rugged obsidian 45. Check it out before you commit to the other ones mentioned above (also good). It is one of the quietest (or quietest perhaps) .45 in the "long" configuration. It can be shortened up as well. It'll handle multiple calibers.

For what it's worth, a baffle stack is reported to be quieter than a monocore. I don't have any actual experience with monocores, I only have baffle stack silencers.

After a lot of research, this is the route I'm going next year too.