After playing several games, I've come up with what I believe to be some decent sliders that help balance out the game and create a very challeging but realistic experiance. I played as A&M against a bad team (BYU), a good team (Tceh), and a great team (USC), and with these sliders I beat BYU 52-13, beat Tceh 27-14, and beat USC 31-30 on a last second FG.

Quarter length: 8 minutes
Difficulty: Heisman

Sliders (User/CPU):

QB accuracy: 60/60
Pass Blocking: 50/45
WR catching: 90/90 (Gets rid of the unusually high # of drops)
RB ability: 50/50
Run blocking: 45/55

Awareness: 60/60
Knockdowns: 55/50
INTs: 35/25
Break block: 65/60
Tackling: 70/70

FG power: 50/45
FG accuracy: 50/45
Punt power: 55/60
Punt accuracy: 55/65
Kickoff power: 50/50

Oh. and set all penalties to 90, except for offsides should be at 100. Even with that, I only had about 4 penaltiues per game per team. EA has never been very realistic with # of penalties IMO.