It's really, really difficult to imagine a scenario where she would leave that podcast in a better spot than she walked into it.
Joe gets along with people all across the spectrum, that's part of his appeal. But his catch is you have to be at least somewhat genuine. Not that it's explicitly laid out, it's just the way he conducts these conversations necessitates that the person across the table let's their guard down if they want it to go well for them.
Kamala might quite literally be the most disingenuous person to ever hold a spot this powerful in the zeitgeist, which is not something I say flippantly at all. It would be a disaster for her. And not because Joe would even have to go after her or press her at all, in fact I think he would be more hesitant to than you think. His facial expressions would be enough in itself. It's a square peg in a round hole. They might as well not even speak the same language because in a different but very meaningful way, they don't.
To put it another way, it's never a good strategy to to further highlight your biggest weakness by putting yourself in an environment where the only other person in the room is on the complete opposite end of that particular spectrum. Joe, if nothing else, is genuine. Kamala is about as empty as a human being can be. That contrast by itself would make it nearly impossible for her to look good in that setting.
That being said, I hope like hell she's dumb enough to try.