https://www.medicalbrief.co.za/the-red-flags-that-led-to-a-massive-alzheimers-research-scandal/

The red flags that led to a massive Alzheimer's research scandal


https://www.reuters.com/business/healthcare-pharmaceuticals/exclusive-cassava-sciences-faces-us-criminal-probe-tied-alzheimers-drug-sources-2022-07-27/

Exclusive: Cassava Sciences faces U.S. criminal probe tied to Alzheimer's drug, sources say

The authors appeared to have composed figures by piecing together parts of photos from different experiments," says Elisabeth Bik, a molecular biologist and well-known forensic image consultant. "The obtained experimental results might not have been the desired results, and those data might have been changed to … better fit a hypothesis."

Some Alzheimer's experts now suspect Lesn's studies have misdirected Alzheimer's research for 16 years.

This sounds like Covid and other non approved FDA meds.



"The immediate damage is wasted NIH funding and wasted thinking in the field because people use these results as a starting point for their own experiments," says Stanford University neuroscientist Thomas Sdhof, a Nobel laureate and expert on Alzheimer's and related conditions.

Scientists who advance other potential Alzheimer's causes, like immune dysfunction or inflammation, complain about being sidelined by the "amyloid mafia". Forsayeth says the amyloid hypothesis became "the scientific equivalent of the Ptolemaic model of the solar system", in which the sun and planets rotate around earth.

I was assured that scientists are incorruptible.

It appears that ethics were forgotten.

Just like climate scientists.

Why is Casa's stock not dropped to near 0 on this?

When they spiked up two years ago I saw they were in Austin so I went by their offices. 1 small office in an office bldg and no one there.

They are trading at $25.29 on the NASDAQ right now.

High 123.38 on Jul 23, 2021
Low 0.81 on Dec 28, 2018
Avg 19.12 for past 5 years

From 8/17[url=https://markets.businessinsider.com/news/stocks/why-cassava-sciences-stock-is-ripping-higher-today-1031689983][/url]

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Why Cassava Sciences Stock Is Ripping Higher Today
Shares of biotech firm Cassava Sciences Inc (NASDAQ:SAVA) are trading higher Wednesday after new filings showed recent insider buying.

According to a Form 4 filing with the SEC, Cassava director Sanford Robertson purchased 100,000 shares at an average price of $20.69. The shares were purchased in multiple transactions on Aug. 12 at prices ranging from $19.79 to $21.31 per share. Robertson now owns 1.02 million Cassava shares.

According to a separate Form 4 filing, Cassava CFO Eric Schoen purchased 2,500 shares for $19.95 per share on Aug. 12. Following the new buy, Schoen owns a total of 19,800 shares of Cassava.

Cassava Sciences is a clinical-stage biotech company engaged in developing a scientific approach for the treatment and detection of Alzheimer's disease.

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Science has been corrupted for a long time. We had major advancements in the last 300 years and now, not so much. Given the amount of resources available one should expect to see rapid major discoveries, inventions and advances in medical treatment yet we dont and I blame the politicization of science. So much funding goes to waste.

Can't be, once a consensus is reached, the science is settled.

Have made a good chunk of change off of SAVA. Ground breaking work, had some investor hiccups with false information from competitors. My grandfather had Alzheimers, was difficult as he was a huge part of my life, including receiving my eagle scout.

Very old news and mostly debunked. Short sellers of the stock have commissioned several hit pieces over the past year. There has already been an investigation conducted which turned up nothing. The only fraud has been by the short sellers of the stock who have manipulated the share price to make millions.

Stock was well over $100 this time last year. Now in the $20's after going as low as ~$14 following the last hit piece.

People don't understand that work product gonna get put out.

That's the way it is.

Work product gonna ship. And that includes the medical profession.

The curtain got thrown back on this covid.

Whenever something like this comes out, it causes me to reflect and wonder "How many other assumptions in science have been affected by similar incidents? How would we know?"

Never stop questioning science and "truth" at all levels. We will all be better for it.

10thYrSr said:

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Whenever something like this comes out, it causes me to reflect and wonder "How many other assumptions in science have been affected by similar incidents? How would we know?"

Never stop questioning science and "truth" at all levels. We will all be better for it.

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how would we know? more amateur scientists (instead of rampant consumers),

How do we fix it? better money that doesnt incentivize corruption. currently our money corrupts every aspect of checks and balances in any and all institutions that rely on a level of "they wouldn't do that because they're too big."

The medical industry failed during the china virus pandemic. Starting with the Texas Medical board and their instructions to hospitals, clinics, etc which were not effective. There were therapeutics available but no because Trump supported that it and was therefore wrong.

The medical hierarchy at the state and the hospital boards failed us. I remember discussing some of these matters with people I knew during the pandemic and they said if you get the virus then good luck. They offered no treatment.

I was told to "Trust the science." Are we not supposed to do that anymore?

C@LAg said:

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yep. put us 2 decades behind/

our medical research sector is utterly failing us across the board.

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That's because it is littered with liberal covidians that know better than all of us. Just like everything else, liberals ruin every single thing they touch.

Well here's the thing with science and research that most of the public doesn't get to see. The vast majority of projects fail and fail miserably even if there is promise in the initial phases and significant capital involved. Repeated failures actually drive research, not necessarily the discoveries

Romello said:

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Science has been corrupted for a long time. We had major advancements in the last 300 years and now, not so much. Given the amount of resources available one should expect to see rapid major discoveries, inventions and advances in medical treatment yet we dont and I blame the politicization of science. So much funding goes to waste.

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Wrong, we can now treat many chronic diseases (ulcerative colitis, chrons, cystic fibrosis, rheumatoid arthritis) effectively and give people a normal lifespan than we could 20 years ago. Not to mention survival rates for cancer have improved and recurrence rates have decreased with newer meds. Heart failure medications have to lead to normal life spans as well as new antiarrhythmic drugs. It just seems like we previously made more advancements because the things that we did discover were high impact and involved what we would consider basic science by today's standards when at the time it was advanced (like creating penicillin).

10thYrSr said:

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Whenever something like this comes out, it causes me to reflect and wonder "How many other assumptions in science have been affected by similar incidents? How would we know?"

Never stop questioning science and "truth" at all levels. We will all be better for it.

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Hold back from polishing the brass on scientific bandwagons.

thank god i believe in jesus because their is no institutions or people to put your hope or faith in anymore. teachers doctors scientist politicians cops military leaders, the list goes on and on and al of them more or less suck.

Detmersdislocatedshoulder said:

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thank god i believe in jesus because their is no institutions or people to put your hope or faith in anymore. teachers doctors scientist politicians cops military leaders, the list goes on and on and al of them more or less suck.

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Amen. God, family, and friends (close friends). All that matters.

whytho987654 said:

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Romello said:

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Science has been corrupted for a long time. We had major advancements in the last 300 years and now, not so much. Given the amount of resources available one should expect to see rapid major discoveries, inventions and advances in medical treatment yet we dont and I blame the politicization of science. So much funding goes to waste.

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Wrong, we can now treat many chronic diseases (ulcerative colitis, chrons, cystic fibrosis, rheumatoid arthritis) effectively and give people a normal lifespan than we could 20 years ago. Not to mention survival rates for cancer have improved and recurrence rates have decreased with newer meds. Heart failure medications have to lead to normal life spans as well as new antiarrhythmic drugs. It just seems like we previously made more advancements because the things that we did discover were high impact and involved what we would consider basic science by today's standards when at the time it was advanced (like creating penicillin).

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The system is corrupt to it's core. Doctors are influenced at the local level from Big Pharma to push drugs, then those doctors push them on other doctors for money and free vacations. Also, the researchers make the real cash, and many of the studies we end up with are positive toward big pharma. Its a huge failure, and many doctors agree.


Also this was not a "failure", well it was, then it went from failure to fraud.

Perfect example is blood pressure medications that many Kidney doctors have been using, but now we know they actually CAUSE kidney damage. LOL, but I guess this was a "success" of modern medications.

https://news.virginia.edu/content/long-term-use-blood-pressure-drugs-may-cause-kidney-damage-study-suggests


New kidney research from the University of Virginia School of Medicine is raising concerns that long-term use of drugs commonly prescribed to treat high-blood pressure and heart failure could be contributing to kidney damage.

Patients should continue taking the medications, which include the well-known and widely used ACE inhibitors, the researchers say. But the scientists are urging studies to better understand the drugs' long-term effects.

samurai_science said:

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whytho987654 said:

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Romello said:

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Science has been corrupted for a long time. We had major advancements in the last 300 years and now, not so much. Given the amount of resources available one should expect to see rapid major discoveries, inventions and advances in medical treatment yet we dont and I blame the politicization of science. So much funding goes to waste.

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Wrong, we can now treat many chronic diseases (ulcerative colitis, chrons, cystic fibrosis, rheumatoid arthritis) effectively and give people a normal lifespan than we could 20 years ago. Not to mention survival rates for cancer have improved and recurrence rates have decreased with newer meds. Heart failure medications have to lead to normal life spans as well as new antiarrhythmic drugs. It just seems like we previously made more advancements because the things that we did discover were high impact and involved what we would consider basic science by today's standards when at the time it was advanced (like creating penicillin).

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The system is corrupt to it's core. Doctors are influenced at the local level from Big Pharma to push drugs, then those doctors push them on other doctors for money and free vacations. Also, the researchers make the real cash, and many of the studies we end up with are positive toward big pharma. Its a huge failure, and many doctors agree.


Also this was not a "failure", well it was, then it went from failure to fraud.

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This couldn't be farther from the truth. Doctors receive very little from pharm companies most just deny it because an extra 3k from the pharm company is not worth the moral dilemma when theyre already making 300-400k. The vast majority of physicians prefer to prescribe generic versions; they cost less and work the same. The real problem is the insurance. They surprise surprise often won't cover the generic but will cover the expensive name brand and have the patient pay 2x out of pocket what they would for the generic. And as far as researchers go, for everyone making bank doing research (let's say 300k), there are 1000 researchers making under 100k.

samurai_science said:

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Perfect example is blood pressure medications that many Kidney doctors have been using, but now we know they actually CAUSE kidney damage. LOL, but I guess this was a "success" of modern medications.

https://news.virginia.edu/content/long-term-use-blood-pressure-drugs-may-cause-kidney-damage-study-suggests


New kidney research from the University of Virginia School of Medicine is raising concerns that long-term use of drugs commonly prescribed to treat high-blood pressure and heart failure could be contributing to kidney damage.

Patients should continue taking the medications, which include the well-known and widely used ACE inhibitors, the researchers say. But the scientists are urging studies to better understand the drugs' long-term effects.

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There's a major confounding variable, hypertension will lead to kidney disease and kidney failure if untreated. ACE-I does a good job of treating HTN, but if a patient has an unhealthy lifestyle there's only so much the ACE-I can do.

Also, people with HTN are more likely to have diabetes, which is also related to kidney disease (diabetic nephropathy). Sure there is corruption in science/medicine/research at some levels, but its not black and white like this thread makes it out to be.

not everyone is convinced that beta-amyloid is the only cause of alzheimer's -- thats why it is called the "amyloid hypothesis" -- however, it is probably the leading theory

in general, the theory suggests that Amyloid Precursor Proteins (APPs) are broken down -- one of these pieces is the beta-amyloid -- one portion of beta-amyloid, AB42, accumulates and forms plaques. this then causes "hyper-phosphorylation" of another protein, Tau, which ultimately leads to "Tau tangles" and neuro-degeneration.

AB42 has been placed in knockout mice and lead to an alzheimer's picture w/ cell death
AB*56 itself has not been a hot drug target

however, the 1 anti-amyloid medication that is out has shown radiographic & clinical benefit; and the 3 that are coming out look even better -- so 4 different drug companies coming up with similar studies -- these target beta-amyloid in general

so even if this researcher did forge all that data (which I'm not sure I believe) it would be quite a coincidence to see all of the things we are seeing

the amyloid hypothesis is not the only target in alzheimer's research, so even if this hit piece is correct, it did not set the alzheimer's research "back 16yrs"

the near future for dementia appears very bright

They forgot to trust the science?

Signel said:

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They forgot to trust the science?

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Nahhhh they forgot that the scientific method is at its core about testing rigorously to obtain reproducible results

OasisMan said:

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the near future for dementia appears very bright

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The short term however looks to be very forgettable.

Yet…

https://www.globenewswire.com/news-release/2022/08/18/2500964/8339/en/No-Evidence-of-Data-Manipulation-in-Science-Publication-on-Simufilam.html

Awful, now do cancer.

Philip J Fry said:

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Yet…

https://www.globenewswire.com/news-release/2022/08/18/2500964/8339/en/No-Evidence-of-Data-Manipulation-in-Science-Publication-on-Simufilam.html

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The problem with this story is there are multiple different things that are all true. That makes message boards self destruct.

The amyloid beta hypothesis may be wrong.

One researcher who was a proponent of the amyloid beta hypothesis may have faked some data 15 years ago.

The vast majority of people (and companies) working on the amyloid beta hypothesis haven't faked data or done anything unethical.

Almost every drug development program fails.

Wait for the treatments using psychedelic drugs like LSD and shrooms. They're going to try it on everything. Depression, alcoholism, Alzheimer's, etc. Next wave of pharmaceutical treatments coming our way.