The most recent season of Arrested Development got me thinking:

TV shows used to be episodic (for example, X-Files), where each episode could stand on it's own and few episodes were vital to the overall course of the show. This way, if someone missed a single episode except for the season finale, they weren't lost in the plot.

With the advent of DVRs and later streaming services, TV shows became more serialized (for example Breaking Bad), where an single storyline is spread out over the entire season. This allows more time for character and plot development and audiences don't have to be on the couch at 7 pm sharp every Wednesday.

...but that all applies to dramas. I was trying to think about sitcoms and I realized that even in the age of streaming video, my favorite sitcoms are episodic: The Office, Parks and Rec, Brooklyn 99, Rick & Morty

The two examples of serialized sitcoms I can think of Arrested Development 4/5 & South Park in 2016 were both lower quality than their previous iterations.

Am I missing some examples of good serial sitcoms or does comedy not apply itself as well to a serialized version?

it is much harder serialized because the same subject/jokes get tiring after a while. Episodic nature allows the story and jokes to go all over the place.

other sitcoms do go somewhat serialized, but only through smaller arcs where the episodes are still episodic, but there is an overarching story as well (see Scrubs, Friends). But the show, overall is still mostly episodic.

Veep, Silicon Valley, Barry, and You're the Worst are all serialized and they are all fantastic.

Vice Principals?

Soap (1977-81)
Kimmy Schmidt
Last Man on Earth

East Bound and Down.
Jimmy Schmidt

Love on Netflix.

There are some good examples here, but in general I think the broadcast sitcom format really limits the ability to tell serialized stories in half hour blocks. The 22-23 minute format requires commercial breaks which means telling a story in 3 acts and that just tends to be difficult to tell good narratives. Punchy jokes flow better and are more accessible to audiences.

Even in the examples that have been listed so far, most if not all, are from streaming services or premium providers who don't rely on ads to sell content and thus can break the traditional format. The one's from Fox and FX have ad breaks, but often experiment with 2-Act formats and longer ads in the middle so it feels like deeper stories.

I'm having trouble coming up with any current broadcast or basic cable sitcoms that could be considered serialized, good or otherwise. Probably not popular with this audience but Younger is the only one I can think of.

The Good Place! I knew I'd come up with one. Highly serialized.