Dramamine works nicely till you puke it up.
Honestly, my best times have been when I've taken Dramamine the night before (no less than 12 hours before departure), morning of, then an hour or so in to the trip. My good luck breakfast is always a whole green bell peppper.
Without fail, I get sick within hours... but the sickness is not nearly as bad without the precautions. Oh, and keep drinking water. And OJ (works for me) is good, too.
Good luck.