https://www.nejm.org/doi/full/10.1056/NEJMoa2015432?query=featured_home


Small autopsy study comparing COVID-19 to H1N1 and control patients. COVID-19 patients distinguished by widespread pulmonary angiopathy and small vessel thrombosis. Even more compelling evidence to anticoagulate all hospitalized patients or at least ICU patients.

I truly believe this a disease of oxidative stress acting the endothelium. Once the endothelium is damaged by increasing oxidative stress it releases Von Willebrands factor and factor VIII from the endothelium. One study showed both VWF and VIII to be over 500% higher in ICU COVID-19 patients. Once these factors are released massive clotting begins. I agree that anti-coagulation is likely going to be a mainstay treatment. I don't know if you can get a vWF level in your hospital but I think in the study elevated levels of vWF were also predictive of outcomes. I can probably find the study if you want it Marcus.

Another interesting point is Type O blood which had a lower rates of infection in China have a lower vWF than other blood types. Also African Americans have higher levels of vWF than Caucasians so this along with African Americans being poor absorbers of Vitamin D could be a reason for the higher rate of African American patients in the hospital.

aggiebrad94 said:

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Would anti-inflammatory supplements (tumeric, curcumin, etc) be wise to take, then?

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I am using NAC and CoQ10 to decrease oxidative stress. However, there is data on Turmeric decreasing oxidative stress in the body so it will likely be beneficial also. It's just been a while since I have reviewed those studies.