Are you driving? We left Prague and took a night to make a loop east to Kutna Hora, then north and back west to Dresden. Two nights there and then a night to loop kind of west back down to Prague. Many of the places we stopped the locals acted like we were the first Americans they had ever seen. Little town of Oybin, Germany was really cool. Saxon Switzerland was nice, The armoury museum in Dresden is one of the best in the world. I can give recommendations on food and lodging if needed.