My FIL has a place and boat in the middle keys, so we go there every summer. We fly into FTL and rent a car. We will make the trip to Key West once a trip. Like was mentioned earlier, you're usually driving at 40-50 mph, so don't be in a hurry. There are a ton of great beaches and restaurants. We like to spend an afternoon or day at a reef and/or sandbar. A day in Key West shopping. Maybe a day sport fishing. We've also visited the Turtle Hospital and swam in the Aquarium in Marathon. I highly recommend both. US dollars are accepted, English is spoken, it's a short flight, and you're protected by the Constitution. So yeah, great place to go for a vacation.