Had a client there a few years ago. There was a nice clean friendly downtown. And the 500 is pretty awesome. There's a place downtown whose shrimp cocktail (the sauce actually) will peel the first couple of layers off the roof of your mouth which is a well needed distraction since your nostril hairs will be singed off.
ETA: client was directly north of downtown, i stayed about a block away from Conseco Fieldhouse in the southern portion of downtown. From my experiences screwing around driving aimlessly, South side bad, North side good. I judge neighborhoods by their grocery stores. North of downtown there were some fancy krogers. South of downtown some sketchy AF independent grocers with ancient cash registers and wack "name" brands.