The 454 wasn't brutal in recoil, but the muzzle blast would blow an empty cartridge box off the bench when I was shooting it, standing.
I was afraid that shooting it without protection would cause serious hearing damage. It made a great 45LC to carry with heavy loads, though.
A heavy 45LC can equal a 44 Mag. A 454 is... 3? Times the energy of a 44?
I think it's irrelevant from a short barreled gun. I don't think a pistol round, other than 460 S&W, 500 S&W or 5.7x28 can go fast enough to would differently than by being a pointy stick, and I think a heavy 45 LC or 44 Mag has enough penetration to work fine on game.
I suppose the bigger rounds can drive a JHP deep enough through a bear, etc.