3-D printed ovaries yield new life

3,740 Views | 29 Replies | Last: 6 yr ago by AggieBand2004
Woody2006
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AG
http://blogs.discovermagazine.com/d-brief/2017/05/16/3d-printed-ovaries-mice/#.WSS9o2jyuUk
Quote:

Mice with artificial, 3-D printed ovaries have successfully given birth to healthy offspring.

It's another success for members of the same Northwestern University team that in March reproduced an entire menstrual cycle using organs-on-a-chip. This time, they've created ovaries from a type of gelatin hydrogel and infused them with immature egg cells before implanting them in female mice. The ovaries behaved like the natural ones, picking out an egg cell to mature and pass along, allowing the mice to bear healthy offspring. The procedure marks another step toward printing replacements for missing or damaged organs.
Quote:

The results are nevertheless encouraging, both because they hint at the development of other 3-D printed organs and because they represent another encouraging development for women whose ovaries have been damaged or removed. Some cancer treatments can render women infertile, and Woodruff's lab has been searching for a way to give these women another shot at pregnancy. They've previously experimented with removing and freezing ovaries, and this concept could represent another way to solve the problem.

Actually producing other organs using a similar technique may be even further off, though. Each organ represents its own challenge, and some contain more types of tissue working in concert than ovaries do. Still, as 3-D printing technology becomes more sophisticated and research progresses, it could one day be an option.
G. hirsutum Ag
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AG
I'll stay back and wait for the Epson brand to come out
chipotle
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Those ink cartridges are gonna be expensive.
Al Bula
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AG
Sounds almost like axlotl tanks from Dune. Not quite... but Frank Herbert was onto something when he envisioned growing quasi humans in articficial wombs.

(To any dune purists, yes I know exactly what the axlotl tanks were)
EFE
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AG
GoneGirl
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AG
My own natural ones tried to kill me. I wonder if these would be more hospitable...

GoneGirl
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AG
so true I had to say it twice.
80s Guy
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EagleFordEarl said:




One step closer to Keanu being our only hope

Goose83
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AG
Does this mean I can now print my own personal Milla Jovovich?


Lungblood
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What could possibly go wrong?
Direct Enter Enter
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Reminds me of the Doctor Who episode "the Rebel Flesh", where hazmat workers use some sort of an organic plastic goo to mold clones of themselves, controlled remotely, to physically handle the hazmat. Of course the remote control connections fail and the goo-clones start thinking for themselves.
HBCanine08
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AG
that was a f-ed up episode.
eeinhouston
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I volunteer to re-load the printer.
SpreadsheetAg
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AG
My daughter (3.5 yo) has Grade 3 microtia of her right ear (the pinna / out ear is underdeveloped). Her middle ear and inner ear are fine, just the outer ear is affected. We are hoping to use 3D printing technology with bio-ink to print her a copy of her left ear and implant it on the right side and let the blood vessels and skin take over.

Normal corrective procedure call for taking rib tissue and 4-5 operations of grafting, and reshaping to fix. With a 3d printer, only 1 operation is needed.
GoneGirl
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AG
SpreadsheetAg said:

My daughter (3.5 yo) has Grade 3 microtia of her right ear (the pinna / out ear is underdeveloped). Her middle ear and inner ear are fine, just the outer ear is affected. We are hoping to use 3D printing technology with bio-ink to print her a copy of her left ear and implant it on the right side and let the blood vessels and skin take over.

Normal corrective procedure call for taking rib tissue and 4-5 operations of grafting, and reshaping to fix. With a 3d printer, only 1 operation is needed.
That is just so freaking awesome. I love some of the stuff that's being done with the printers.
CDUB98
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AG
That's awesome, Spreadsheet.
agracer
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AG
Woody2006 said:

http://blogs.discovermagazine.com/d-brief/2017/05/16/3d-printed-ovaries-mice/#.WSS9o2jyuUk
Quote:

Mice with artificial, 3-D printed ovaries have successfully given birth to healthy offspring.

It's another success for members of the same Northwestern University team that in March reproduced an entire menstrual cycle using organs-on-a-chip. This time, they've created ovaries from a type of gelatin hydrogel and infused them with immature egg cells before implanting them in female mice. The ovaries behaved like the natural ones, picking out an egg cell to mature and pass along, allowing the mice to bear healthy offspring. The procedure marks another step toward printing replacements for missing or damaged organs.
Quote:

The results are nevertheless encouraging, both because they hint at the development of other 3-D printed organs and because they represent another encouraging development for women whose ovaries have been damaged or removed. Some cancer treatments can render women infertile, and Woodruff's lab has been searching for a way to give these women another shot at pregnancy. They've previously experimented with removing and freezing ovaries, and this concept could represent another way to solve the problem.

Actually producing other organs using a similar technique may be even further off, though. Each organ represents its own challenge, and some contain more types of tissue working in concert than ovaries do. Still, as 3-D printing technology becomes more sophisticated and research progresses, it could one day be an option.

If they can harness this to other body parts (IE breasts) they'd have an actual market for making money.
SpreadsheetAg
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AG
agracer said:

Woody2006 said:

http://blogs.discovermagazine.com/d-brief/2017/05/16/3d-printed-ovaries-mice/#.WSS9o2jyuUk
Quote:

Mice with artificial, 3-D printed ovaries have successfully given birth to healthy offspring.

It's another success for members of the same Northwestern University team that in March reproduced an entire menstrual cycle using organs-on-a-chip. This time, they've created ovaries from a type of gelatin hydrogel and infused them with immature egg cells before implanting them in female mice. The ovaries behaved like the natural ones, picking out an egg cell to mature and pass along, allowing the mice to bear healthy offspring. The procedure marks another step toward printing replacements for missing or damaged organs.
Quote:

The results are nevertheless encouraging, both because they hint at the development of other 3-D printed organs and because they represent another encouraging development for women whose ovaries have been damaged or removed. Some cancer treatments can render women infertile, and Woodruff's lab has been searching for a way to give these women another shot at pregnancy. They've previously experimented with removing and freezing ovaries, and this concept could represent another way to solve the problem.

Actually producing other organs using a similar technique may be even further off, though. Each organ represents its own challenge, and some contain more types of tissue working in concert than ovaries do. Still, as 3-D printing technology becomes more sophisticated and research progresses, it could one day be an option.

If they can harness this to other body parts (IE breasts) they'd have an actual market for making money.
Here come the rich Chinese multi-millionaires with their 10" *****es
Iowaggie
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AG
Michael Carbonaro has already created realistic butterflies.

SpreadsheetAg
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AG
Got me but realized what happened after about 3 seconds
Know Your Enemy
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AG
Hi, Im Brett
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AG
CW Griswold
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Loretta doesn't need a box anymore.

GoneGirl
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AG
SpreadsheetAg said:

agracer said:

Woody2006 said:

http://blogs.discovermagazine.com/d-brief/2017/05/16/3d-printed-ovaries-mice/#.WSS9o2jyuUk
Quote:

Mice with artificial, 3-D printed ovaries have successfully given birth to healthy offspring.

It's another success for members of the same Northwestern University team that in March reproduced an entire menstrual cycle using organs-on-a-chip. This time, they've created ovaries from a type of gelatin hydrogel and infused them with immature egg cells before implanting them in female mice. The ovaries behaved like the natural ones, picking out an egg cell to mature and pass along, allowing the mice to bear healthy offspring. The procedure marks another step toward printing replacements for missing or damaged organs.
Quote:

The results are nevertheless encouraging, both because they hint at the development of other 3-D printed organs and because they represent another encouraging development for women whose ovaries have been damaged or removed. Some cancer treatments can render women infertile, and Woodruff's lab has been searching for a way to give these women another shot at pregnancy. They've previously experimented with removing and freezing ovaries, and this concept could represent another way to solve the problem.

Actually producing other organs using a similar technique may be even further off, though. Each organ represents its own challenge, and some contain more types of tissue working in concert than ovaries do. Still, as 3-D printing technology becomes more sophisticated and research progresses, it could one day be an option.

If they can harness this to other body parts (IE breasts) they'd have an actual market for making money.
Here come the rich Chinese multi-millionaires with their 10" *****es
You think the President could print himself bigger hands?
Woody2006
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AG
agracer said:

Woody2006 said:

http://blogs.discovermagazine.com/d-brief/2017/05/16/3d-printed-ovaries-mice/#.WSS9o2jyuUk
Quote:

Mice with artificial, 3-D printed ovaries have successfully given birth to healthy offspring.

It's another success for members of the same Northwestern University team that in March reproduced an entire menstrual cycle using organs-on-a-chip. This time, they've created ovaries from a type of gelatin hydrogel and infused them with immature egg cells before implanting them in female mice. The ovaries behaved like the natural ones, picking out an egg cell to mature and pass along, allowing the mice to bear healthy offspring. The procedure marks another step toward printing replacements for missing or damaged organs.
Quote:

The results are nevertheless encouraging, both because they hint at the development of other 3-D printed organs and because they represent another encouraging development for women whose ovaries have been damaged or removed. Some cancer treatments can render women infertile, and Woodruff's lab has been searching for a way to give these women another shot at pregnancy. They've previously experimented with removing and freezing ovaries, and this concept could represent another way to solve the problem.

Actually producing other organs using a similar technique may be even further off, though. Each organ represents its own challenge, and some contain more types of tissue working in concert than ovaries do. Still, as 3-D printing technology becomes more sophisticated and research progresses, it could one day be an option.

If they can harness this to other body parts (IE breasts) they'd have an actual market for making money.
You don't think women who can't have children but desperately want to would be willing to pay for new ovaries?
agracer
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AG
Woody2006 said:

agracer said:

Woody2006 said:

http://blogs.discovermagazine.com/d-brief/2017/05/16/3d-printed-ovaries-mice/#.WSS9o2jyuUk
Quote:

Mice with artificial, 3-D printed ovaries have successfully given birth to healthy offspring.

It's another success for members of the same Northwestern University team that in March reproduced an entire menstrual cycle using organs-on-a-chip. This time, they've created ovaries from a type of gelatin hydrogel and infused them with immature egg cells before implanting them in female mice. The ovaries behaved like the natural ones, picking out an egg cell to mature and pass along, allowing the mice to bear healthy offspring. The procedure marks another step toward printing replacements for missing or damaged organs.
Quote:

The results are nevertheless encouraging, both because they hint at the development of other 3-D printed organs and because they represent another encouraging development for women whose ovaries have been damaged or removed. Some cancer treatments can render women infertile, and Woodruff's lab has been searching for a way to give these women another shot at pregnancy. They've previously experimented with removing and freezing ovaries, and this concept could represent another way to solve the problem.

Actually producing other organs using a similar technique may be even further off, though. Each organ represents its own challenge, and some contain more types of tissue working in concert than ovaries do. Still, as 3-D printing technology becomes more sophisticated and research progresses, it could one day be an option.

If they can harness this to other body parts (IE breasts) they'd have an actual market for making money.
You don't think women who can't have children but desperately want to would be willing to pay for new ovaries?
No, but the women who want new ovaries is a much smaller market than the women would like larger breasts?
AgGrad99
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AG
SpreadsheetAg said:

My daughter (3.5 yo) has Grade 3 microtia of her right ear (the pinna / out ear is underdeveloped). Her middle ear and inner ear are fine, just the outer ear is affected. We are hoping to use 3D printing technology with bio-ink to print her a copy of her left ear and implant it on the right side and let the blood vessels and skin take over.

Normal corrective procedure call for taking rib tissue and 4-5 operations of grafting, and reshaping to fix. With a 3d printer, only 1 operation is needed.
That is incredilble.

How long will it take, after surgery, for the skin/vessels to grow in completely?

As she gets older, will they have to do another surgery for her ear as it grows? Or will she just have one ear slightly smaller than the other?

SpreadsheetAg
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AG


Quote:

The custom bioprinter makes the implants by carefully layering patterns of cell-containing gels and biodegradable, plastic-like materials. Then, the printer adds a temporary polymer outer shell that helps the entire structure hold up during implantation. The printing process has been fine-tuned to ensure that cells remain alive until surgery. Once implanted in an organism, the plastic-like materials slowly degrade. At the same time, the cells secrete a supporting matrix that helps maintain the implant's shape. By the end of this process, the cells have reorganized themselves in a self-sufficient manner that negates the need for supporting materials.
Quote:

To test the implants, the scientists inserted them under the skin of mice and rats. The structures showed promise; two months later, the ears, which were implanted in mice, had kept their shape and proper cartilage tissue had formed. For the muscle, the researchers found that two weeks after the surgery, the muscle implant had prompted nerve formation in rats. Finally, the bone implants, which were printed using human stem cells and implanted in rats, triggered the formation of a blood vessel system that was observable after five months.
SpreadsheetAg
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AG
AgGrad99 said:

SpreadsheetAg said:

My daughter (3.5 yo) has Grade 3 microtia of her right ear (the pinna / out ear is underdeveloped). Her middle ear and inner ear are fine, just the outer ear is affected. We are hoping to use 3D printing technology with bio-ink to print her a copy of her left ear and implant it on the right side and let the blood vessels and skin take over.

Normal corrective procedure call for taking rib tissue and 4-5 operations of grafting, and reshaping to fix. With a 3d printer, only 1 operation is needed.
That is incredilble.

How long will it take, after surgery, for the skin/vessels to grow in completely?

As she gets older, will they have to do another surgery for her ear as it grows? Or will she just have one ear slightly smaller than the other?


Not sure; we're hoping that the technology is more viable by the time she needs to procedure done -405 years from now. It's nearing clinical trials, from our understanding, and I've been putting out feelers to different research groups about signing up for the trials.

Fingers-crossed.
SpreadsheetAg
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AG
Here's a paper from our own Bio-Engineering labs at TAMU

http://people.tamu.edu/~gaharwar/Journal_Papers/Chimene_ABME_2016.pdf

GAHARWAR Labs at TAMU:
http://people.tamu.edu/~gaharwar/Research.html
AggieBand2004
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AG
We make 3D printed dental implants at work. The materials have come a long way
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