Primanti Brothers - Awesome sandwiches and a Pittsburg Icon.
Church Brew Works - Really cool place. They turned an old cathedral into a brewery and bar... kinda weird but cool.
Iron City Brewery
Take the Trolley up to the top of Mount Washington... take in the best view of the city, get drunk and eat at the bar on the hill(forgot name) and then take the Trolley back down the hill.
Hard Rock Cafe -
http://www.hardrock.com/Locations/cafes3/cafe.aspx?LocationID=87&MIBEnumID=3Andy Warhol Museum
Frank Lloyd Wright's Fallingwater and Kentuck Knob -
http://pittsburgh.about.com/cs/fallingwater/a/fallingwater.htmThere is also some pretty country side around the city out of town... as I am sure you will run into on the way to Falling Water.
It is a neat city!
[This message has been edited by jpb1999 (edited 2/6/2009 3:27p).]