290-610-45 just leave town by 5:20. I just did a Pasadena trip and it was AWFUL. I made the mistake if leaving at 6 and got stuck in 7:20 traffic on 290.
I took above posters route to Hobby earlier the month. if your going during non heavy traffic times, this i the quickest route. if traveling during heavy traffic times, Beltway 8 South toll road might be a good option if you don't mind paying the $10 dollars in toll fees to avoid the traffic. comes out on hwy. 45 a couple of miles before the Hobby Airport exit.
Wake Jim Backus up on the pool table, throw him into the shower, pile into his twice engine private plane,learn how to make the manhattans and have him fly you to Hobby......
HELL of a lot easier and safer than driving from CS to Hobby !