I know these can be hit or miss, but this one is by far the best one yet, IMO.
Brad Pitt Between Two Ferns

This is funny - how long has it been going on?

That is hilarious.

Funny

That tan question

That was a good one, though I wish I could still believe that the actors aren't in on it. Though, I do think he does a good job of getting them to be actually annoyed, not just act like it.

I hadn't seen Barry's. I hate that dude in the White House, but it takes a pretty good sense of humor about yourself to go through that.

Bradley cooper still has the best one. But yeah zach looking at portman's dog's dick is a close second.

Ok, just went back and rewatched both. I take it back, Natalie portman's is the best.

to Ben Stiller:

"Do you ever wish you had followed your parents into comedy?"

Bieber is my favorite. "You've had three hairstyles. What's next for your career?"

lol'ed hard at the line about his dad buying him a playgirl subscription for graduating from junior high.